Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p449 | Other diseases of bone and mineral metabolism | ECTS2016

MSC injection modulates osteocyte number after high dose single limb irradiation in a murine model

Benaitreau Delphine , Wade-Gueye Marieme , Alexandre Ribault , Claire Squiban , Stephane Flamant , Radia Tamarat

Introduction: In accidental irradiations, skin, muscle and bone are altered. Mesenchymal Stem Cell (MSC) treatment has already been used for skin healing in accidental irradiations, but its effects on irradiated bone are still unknown.In this study, we characterised a mouse model of high dose local irradiation of bone and the effects of MSCs injections on osteoradionecrosis.Methods: Nude mice were locally irradiated in the left tib...